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Search Results for " anxiolytic activity "

64

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1292	Tiapride hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Tiapride 是一种大脑中 D2/3 多巴胺受体的选择性阻滞剂。它用于治疗各种精神和神经系统疾病，包括运动障碍、酒精戒断综合征、精神病的阴性症状以及老年人的攻击和激动。
T2599	Pirenperone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pirenperone 是5-HT2血清素受体拮抗剂，具有一定抗焦虑作用。
T13318	VU0650786	GluR	Neuroscience
	VU0650786 是能透过中枢神经系统的，选择性谷氨酸受体亚型 3 的一种负变构调节剂，IC50值为 392 nM，有抗抑郁和抗焦虑活性。
T5135	Flupentixol dihydrochloride 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Flupentixol dihydrochloride 是噻克西酮类试剂，能够用于研究精神分裂症以及抗焦虑和抑郁障碍。
T28662	Saripidem SL-850274,SL-85.0274,SL850274,SL85.0274	Others	Others
	Saripidem (SL-85.0274) 是一种化合物，具有抗焦虑活性。
T28303	Pazinaclone A-77000,DN-2327,DN2327,DN 2327,A 77000,A77000	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Pazinaclone 是一种非苯二氮卓类（GABAA）部分激动剂，具有镇静和抗焦虑活性。
T23007	MM 77 dihydrochloride MM 77二盐酸盐	5-HT Receptor	GPCR/G Protein; Neuroscience
	MM 77 dihydrochloride 是一种有效的 5-HT1A 受体突触后拮抗剂，具有抗焦虑样活性。
T12847	SB-616234-A SB-616234A	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB-616234-A 是选择性的，口服有效的5-HT1B receptor 拮抗剂。SB-616234-A 具有抗焦虑和抗抑郁活性。
T27001	CGS8216 CGS 8216,CGS-8216	Others	Others
	CGS8216 是一种苯二氮卓受体拮抗剂，在高剂量时显示出镇痛活性。CGS8216 具有抗焦虑活性，可用于研究免疫系统疾。
T28887	Suriclone RP-31264,RP31264,RP 31264	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Suriclone (RP 31264) 是一种具有选择性的环吡咯酮类化合物，具有镇静和抗焦虑活性，但镇静作用不显著。Suriclone 通过调节 GABA-A 受体显示出其作用。
T34896	Tofisopam Emandaxin,托非索洋,Grandaxin	Others	Others
	Tofisopam (Grandaxin) 是2,3-苯二氮卓类化合物，具有抗焦虑活性，可口服。
T2359	ANA-12 ANA 12,ANA12	Trk receptor	Tyrosine Kinase/Adaptors
	ANA-12 是一种选择性TrkB 拮抗剂，对高亲和力和低亲和力位点的IC50分别为45.6 nM 和41.1 μM。
T12998	SR10067	Others; Autophagy	Autophagy; Others
	SR10067 是选择性的Rev-Erbα/β的激动剂，其对Rev-Erbβ 和Rev-Erbα 的IC50分别为 160 nM 和 170 nM。SR10067可以透过大脑的。SR10067具有抗焦虑活性。
T27262	Enciprazine WY-48624,D-3112,WY48624,WY 48624,D 3112,D3112	5-HT Receptor	GPCR/G Protein; Neuroscience
	Enciprazine (D-3112) 具有抗焦虑活性，对 5-HT1A 受体和 ADRA1有很高的亲和力，可用于治疗焦虑症，可用于研究抑郁症。
T23470	Tracazolate hydrochloride Tracazolate (hydrochloride),盐酸西卡唑酯	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Tracazolate hydrochloride (Tracazolate (hydrochloride)) 是一种GABAA 受体的调节剂，具有抗焦虑和抗惊厥活性。Tracazolate hydrochloride 能增强α1β1γ2s 和α1β3γ2，EC50s 为13.2μM 和1.5μM。
T16713	R121919 NBI30775	Others	Others
	R121919 (NBI30775) 是一种高效的促肾上腺皮质激素释放因子受体 1 （CRF1）小分子受体拮抗剂，具有抗抑郁和抗焦虑活性，抑制 CRF1 受体、 CRF2 受体和 CRF 结合蛋白。
T68142	Serazapine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Serazapine 是一种高度特异性的血清素（5-HT2）结合抑制剂，具有抗焦虑活性，可用于治疗焦虑症。
T8451	Tropanserin MDL 72422	5-HT Receptor	GPCR/G Protein; Neuroscience
	Tropanserin (MDL 72422) 是一种 5-羟色胺受体拮抗剂，抑制5-HT3受体活性。Tropanserin 具有抗焦虑活性，可用于治疗抑郁症和认知障碍。
T71138L	Binospirone MDL 73005EF	5-HT Receptor	GPCR/G Protein; Neuroscience
	Binospirone (MDL 73005EF) 是一种 5-HT1A 受体激动剂，具有抗焦虑活性，可用于研究青光眼和与神经功能障碍相关的运动障碍。
T13329	Vofopitant GR 205171	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Vofopitant (GR 205171) 是一种有效的 NK1 receptor 拮抗剂，具有抗焦虑和止吐活性，可用于研究创伤后应激障碍(PTSD)。
T83651	AC-263093	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	AC-263093 是一种选择性 NPFFR2 激动剂，具有抗焦虑活性，可增加下丘脑室旁核中的c-Fos蛋白表达。
T61816	EMD 56551	5-HT Receptor	GPCR/G Protein; Neuroscience
	EMD 56551 是一种具有选择性的小分子 5-HT1A 受体激动剂，具有抗焦虑活性，可用于研究焦虑症。
T23509	VU 0285683	GluR	Neuroscience
	VU 0285683 是 mGluR5 的特异性负变构调节剂，对 MPEP 结合位点具有高亲和力。 VU 0285683 表现出抗焦虑样活性。
T23335	SCH 221510 SCH-221510,SCH221510	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	SCH 221510 是一种可口服且具有选择性和有效性的 NOP 激动剂，其 EC50 为12 nM，Ki 为 0.3 nM。SCH 221510 具有抗焦虑活性，可用研究神经系统疾病。
T68047	Clopipazan	Others	Others
	Clopipazan 是一种抗精神病和抗抑郁病化合物。Clopipazan 具有镇静和抗焦虑活性，可能由于选择性阻断某些中间神经元的GABergic发挥作用。
T4176	rac-BHFF (R,S)-BHFF	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	rac-BHFF ((R,S)-BHFF) 是具有口服活性的 GABAB 受体的异构增强剂，有抗焦虑活性。
T16265	Naluzotan PRX 00023	EGFR; 5-HT Receptor	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	Naluzotan（PRX 00023）是一种新型高效的 5-HT1A 激动剂，IC50 和 Ki 值分别为约 20 nM 和 5.1 nM。Naluzotan 是一种有效的 hERG K+ 通道阻滞剂，IC50 值为 3800 nM。Naluzotan 具有抗焦虑活性，可用于研究抑郁症。
T16489	Darigabat CVL-865,PF-6372865,PF-06372865	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Darigabat (PF-06372865) 是一种可穿过血脑屏障且具有口服活性和选择性的 GABAA 受体调节剂，具有抗焦虑活性，对 α2、α1 PAM、α2 PAM 的 Ki 值分别为 2.9 nM、21 nM、134 nM。Darigabat 可用于研究焦虑症和癫痫。
T15275	Fenobam	GluR	Neuroscience
	Fenobam 是可口服的、可穿过血脑屏障的 mGluR5拮抗剂，具有抗焦虑活性，在大鼠和人重组 mGlu5 受体上的 Kd 值分别 54 和 31 nM。它有反向激动剂活性，可阻断 mGlu5 受体活性，IC50为 84 nM。
T50048	4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one	Others	Others
	4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one 是一种苯二氮卓类衍生物，GABAA 受体的正变构调节剂，选择性地与 GABAA 受体的苯二氮卓类位点结合，具有抗焦虑、抗惊厥和镇静的活性。
T10198	8-M-PDOT 8-Methoxy-2-propionamidotetralin,AH-002	MT Receptor	Neuroscience
	8-M-PDOT (AH-002) 是一种具有选择性和有效性的褪黑激素 MT2 受体激动剂，对 MT1 受体也具有抑制作用。8-M-PDOT 具有抗焦虑活性，可用于研究由 MT2 诱导的神经疼痛。
T25672	Lesopitron	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lesopitron 是一种具有突触前和突触后5-HT1A 激动剂活性的抗焦虑剂，在大鼠社会交往和狨猴焦虑模型中比5-HT1A 激动剂更有效。Lesopitron 能对抗苯二氮卓类药物戒断引起的啮齿动物的焦虑且急性毒性很低，不会增强酒精或巴比妥类药物的作用。
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
TP2068L	Cyclotraxin B acetate(1203586-72-4 free base)	Trk receptor	Tyrosine Kinase/Adaptors
	Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂；抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。
T15286	Flindokalner BMS-204352	Potassium Channel	Membrane transporter/Ion channel
	Flindokalner (BMS-204352) 是一种钾离子通道调节剂。它是大电导钙激活 K 通道正向调节剂。它是在 HEK293 细胞中表达的所有神经元 Kv7通道亚型的正调节剂。它在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性，并充当 GABAA 受体的负调节剂。它在体内显示出抗焦虑功效。
TP1930L1	Spexin acetate(1370290-58-6 free base)	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Spexin acetate(1370290-58-6 free base) 是一种有效的甘丙肽受体 2/3 (GAL2/GAL3) 激动剂（EC50 值分别为 45.7 和 112.2 nM）。对甘丙肽受体 1 没有显着的活性。抑制脂肪细胞对长链脂肪酸的摄取并减少饮食诱导的肥胖小鼠和大鼠的食物消耗。减少金鱼的 LH 分泌。在体内表现出抗焦虑作用。
T27317	FG-5893 FG 5893
	FG-5893 is a 5-HT1A agonist and 5-HT2 antagonist with potential anxiolytic activity.
T29892	alpha-Casozepine Lactium
	alpha-Casozepine is a fragment of alpha(s1)-casein with anxiolytic activity.
T71357	AZD-3783
	AZD-3783 is a selective 5-hydroxytryptamine 1B receptor antagonist with probable antidepressant and anxiolytic activity.
T27149	Deramciclane fumarate
	Deramciclane fumarate is a 5-HT(2A/C) antagonist with putative anxiolytic activity.
T27843	Lometraline hydrochloride CP-14,368-1,UNII-T2OJ193WGR,Lometraline HCl,CP 14,368-1
	Lometraline hydrochloride is a drug which is an aminotetralin derivative with the potential activity of antidepressant and/or anxiolytic.
T34558	SC-48274 SC 48274,SC48274
	SC-48274是一种新型抗焦虑药。SC-48274具有与丁螺环酮相同效力的抗焦虑活性，并且需要重复剂量给药来诱导抗焦虑活性。
T10302	Amibegron hydrochloride SR 58611A	Others	Others
	Amibegron hydrochloride is a selective β3-adrenoceptor agonist (EC50: 3.5 nM for β-adrenoceptor in rat colon). It has anxiolytic and antidepressant activity.
T15026	Cyamemazine	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 nM) receptors antagonist with antipsychotic activity.
T27379	FR-194921 FR194921
	FR-194921 is a potent, selective, and orally active antagonist for central adenosine A1 receptors with cognitive-enhancing and anxiolytic activity. FR194921 has same binding affinity profile among human, rat, and mouse.
T29151	WAY267464 HCl WAY267464,WAY-267464,WAY 267,464 dihydrochloride,WAY-267,464 dihydrochloride,WAY 267464 dihydrochloride,WAY 267464
	WAY267464 is a nonpeptide small-molecule OT agonists with anxiolytic activity. WAY267464 may be used for modulation of potency, selectivity over the structurally similar vasopressin receptors, CNS penetration, and oral bioavailability.
T21345	MCOPPB
	MCOPPB is a potent and selective agonist for the nociceptin receptor with a pKi of 10.07, much weaker activity at other opioid receptors. In animal studies, MCOPPB produces potent anxiolytic effects, with no inhibition of motor or memory function, and onl
T29230	ZK-95962
	ZK-95962 is an agonist gamma-aminobutyric acid (GABA) receptor. ZK-95962 had selective effects on releasing exploratory locomotor activity suppressed by footshock (punished crossings). ZK-95962 had weak effects on the measures of anxiolytic activity. The
T68959	Fenobam hydrate
	Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits basal activity of mGluR5. Fenobam reduces stress-induced hyperthermia, exhibits anxiolytic-like activity, and may induce analgesia.
T5406	SNAP 94847 SNAP-94847	GPR; Melanin-concentrating Hormone Receptor (MCHR)	Endocrinology/Hormones; GPCR/G Protein
	SNAP 94847 (SNAP-94847) 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM。它具有抗焦虑和抗抑郁活性，可减少小鼠的食物摄入。

化合物

Tiapride hydrochloride

Cat.No: T1292

Target: Dopamine Receptor

Cat.No: T2599

Target: 5-HT Receptor

Cat.No: T13318

Target: GluR

Flupentixol dihydrochloride

Cat.No: T5135

Synonym: 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride

Target: Dopamine Receptor

Cat.No: T28662

Synonym: SL-850274,SL-85.0274,SL850274,SL85.0274

Target: Others

Cat.No: T28303

Synonym: A-77000,DN-2327,DN2327,DN 2327,A 77000,A77000

Target: GABA Receptor

MM 77 dihydrochloride

Cat.No: T23007

Synonym: MM 77二盐酸盐

Target: 5-HT Receptor

Cat.No: T12847

Synonym: SB-616234A

Target: 5-HT Receptor

Cat.No: T27001

Synonym: CGS 8216,CGS-8216

Target: Others

Cat.No: T28887

Synonym: RP-31264,RP31264,RP 31264

Target: GABA Receptor

Cat.No: T34896

Synonym: Emandaxin,托非索洋,Grandaxin

Target: Others

Cat.No: T2359

Synonym: ANA 12,ANA12

Target: Trk receptor

Cat.No: T12998

Target: Others, Autophagy

Cat.No: T27262

Synonym: WY-48624,D-3112,WY48624,WY 48624,D 3112,D3112

Target: 5-HT Receptor

Tracazolate hydrochloride

Cat.No: T23470

Synonym: Tracazolate (hydrochloride),盐酸西卡唑酯

Target: GABA Receptor

Cat.No: T16713

Synonym: NBI30775

Target: Others

Cat.No: T68142

Target: 5-HT Receptor

Cat.No: T8451

Synonym: MDL 72422

Target: 5-HT Receptor

Cat.No: T71138L

Synonym: MDL 73005EF

Target: 5-HT Receptor

Cat.No: T13329

Synonym: GR 205171

Target: Neurokinin receptor

Cat.No: T83651

Target: Neuropeptide Y Receptor

Cat.No: T61816

Target: 5-HT Receptor

Cat.No: T23509

Target: GluR

Cat.No: T23335

Synonym: SCH-221510,SCH221510

Target: Opioid Receptor

Cat.No: T68047

Target: Others

Cat.No: T4176

Synonym: (R,S)-BHFF

Target: GABA Receptor

Cat.No: T16265

Synonym: PRX 00023

Target: EGFR, 5-HT Receptor

Cat.No: T16489

Synonym: CVL-865,PF-6372865,PF-06372865

Target: GABA Receptor

Cat.No: T15275

Target: GluR

4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

Cat.No: T50048

Target: Others

Cat.No: T10198

Synonym: 8-Methoxy-2-propionamidotetralin,AH-002

Target: MT Receptor

Cat.No: T25672

Target: 5-HT Receptor

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cyclotraxin B acetate(1203586-72-4 free base)

Cat.No: TP2068L

Target: Trk receptor

Cat.No: T15286

Synonym: BMS-204352

Target: Potassium Channel

Spexin acetate(1370290-58-6 free base)

Cat.No: TP1930L1

Target: Neuropeptide Y Receptor

Cat.No: T27317

Synonym: FG 5893

alpha-Casozepine

Cat.No: T29892

Synonym: Lactium

Cat.No: T71357

Deramciclane fumarate

Cat.No: T27149

Lometraline hydrochloride

Cat.No: T27843

Synonym: CP-14,368-1,UNII-T2OJ193WGR,Lometraline HCl,CP 14,368-1

Cat.No: T34558

Synonym: SC 48274,SC48274

Amibegron hydrochloride

Cat.No: T10302

Synonym: SR 58611A

Target: Others

Cat.No: T15026

Target: 5-HT Receptor

Cat.No: T27379

Synonym: FR194921

Cat.No: T29151

Synonym: WAY267464,WAY-267464,WAY 267,464 dihydrochloride,WAY-267,464 dihydrochloride,WAY 267464 dihydrochloride,WAY 267464

Cat.No: T21345

Cat.No: T29230

Fenobam hydrate

Cat.No: T68959

Cat.No: T5406

Synonym: SNAP-94847

Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)

Cat. No.	Product Name	Target	Signaling Pathways
T4S1990	Carvacrol 香荆芥酚,Karvakrol,O-Thymol,cymophenol,香芹酚	Apoptosis; Others; Gamma-secretase; Endogenous Metabolite; Antifungal	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience; Others; Proteases/Proteasome; Stem Cells
	Carvacrol (O-Thymol) 是唇形科植物中的一种单萜酚类天然产物，具有镇痛、抗焦虑、抗抑郁、抗氧化、抗炎和抗癌作用。
TN5166	Trans-Methylisoeugenol	Parasite; GST	Microbiology/Virology; oxidation-reduction
	Trans-Methylisoeugenol 是从 Acorus calamus L 中分离得到的具有杀虫活性的化合物。它是一种天然食用香料，具有抗焦虑和抗抑郁等特性，可对谷胱甘肽 S-转移酶（GSTs）产生中度可逆性抑制作用（对人类 GSTs 的抑制浓度为 0.2 至 5.4 毫摩尔，对大鼠 GSTs 的抑制浓度为 0.4 至 4.9 毫摩尔）。
T6S2227	Spinosin 斯皮诺素,Flavoayamenin	Others	Others
	Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮，从 Zizyphus jujube 种子分离得到，能够激活 Nrf2/HO-1 通路，并抑制 Aβ1-42的产生和聚合。
TN1814	Juncusol 6-甲基灯心草二酚,灯心草酚	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows significant activity against MRSA strains.
TN1678	Gelsevirine 钩吻绿碱	Others	Others
	Gelsevirine has anxiolytic activity, may be via the agonist action of glycine receptor in the brain.
TN5147	Tilifodiolide	IL Receptor; TNF; GABA Receptor	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.

天然产物

Cat.No: T4S1990

Synonym: 香荆芥酚,Karvakrol,O-Thymol,cymophenol,香芹酚

Target: Apoptosis, Others, Gamma-secretase, Endogenous Metabolite, Antifungal

Trans-Methylisoeugenol

Cat.No: TN5166

Target: Parasite, GST

Cat.No: T6S2227

Synonym: 斯皮诺素,Flavoayamenin

Target: Others

Cat.No: TN1814

Synonym: 6-甲基灯心草二酚,灯心草酚

Target: Caspase, Antifection

Cat.No: TN1678

Synonym: 钩吻绿碱

Target: Others

Cat.No: TN5147

Target: IL Receptor, TNF, GABA Receptor

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